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发表论文:

独立工作以来发表:

2020年:

1. Liu R, Zhang Y, Zhai G, Liu T*et al. 2020. A Cell-Free Platform Based on Nisin Biosynthesis for Discovering Novel Lanthipeptides and Guiding Their Overproduction In Vivo. Advanced Science.  

Advanced Science  Download Link

2. Wang M#, Fu A#, Hu B#, Tong Y#, Liu R#, Liu Z, Gu J, Xiang B, Liu J, Jiang W, Shen G, Zhao W, Men D, Deng Z, Yu L, Wei W*, Li Yan*, Liu T*. 2020. Nanopore targeted sequencing for the accurate and comprehensive detection of SARS-CoV-2 and other respiratory viruses. Small. 2002169

Small  Download Link

3. Liu R, Fu A, Deng Z, Li Yan, Liu T*. 2020. Promising methods for detection of novel coronavirus SARS-CoV-2. View. 1:e4.

View  Download Link

2019年:

1. Ma T, Shi B, Ye Z, et al. 2019. Lipid engineering combined with systematic metabolic engineering of Saccharomyces cerevisiae for high-yield production of lycopene[J]. Metabolic engineering.

Metabolic Engineering Download Link

2.Abernathy, M. H., Zhang, Y., Hollinshead, W. D., Wang, G., Baidoo, E. E., Liu, T., & Tang, Y. J. 2019. Comparative studies of glycolytic pathways and channeling under in vitro and in vivo modes.

AIChE Journal Download Link

3. Xiaojie Wang, Zixin Deng, Tiangang Liu*.2019. Marker-free system using ribosomal promoters enhanced xylose/glucose isomerase production in Streptomyces rubiginosus. biotechnology journal,(accepted)

biotechnology journal Download Link

4. Yingying Chang, Baozhong Chai, Yunkun Ding, Min He, Linghui Zheng, Yun Teng, Zixin Deng, Yi Yu*, Tiangang Liu*.2019. Overproduction of gentamicin B in industrial strain Micromonospora echinospora CCTCC M 2018898 by cloning of the missing genes genR and genS. Metabolic engineering communications. (accepted)

Metabolic engineering communications Download Link

5. Bin Shi, Tian Ma, Ziling Ye, Xiaowei Li, Yanglei Huang, Zhiyi Zhou, Yunkun Ding, Zixin Deng and Tiangang Liu*.2019. Systematic Metabolic Engineering of Saccharomyces cerevisiae for Lycopene Overproduction. Journal of Agricultural and Food Chemistry.

Journal of Agricultural and Food Chemistry  Download Link

6. Xiang Sun, You-Sheng Cai, Yujie Yuan, Guangkai Bian, Ziling Ye, Zixin Deng and Tiangang Liu.Genome mining in Trichoderma viride J1-030: discovery and identification of novel sesquiterpene synthase and its products.Beilstein Journal of Organic Chemistry

Beilstein Journal of Organic Chemistry Download Link

7. 程术, 邓子新, 卞光凯, 刘天罡。萜类高效合成平台的搭建与萜类产物批量挖掘。生命科学, 20195449-457

生命科学  Download Link

2018年:

1. Yuan Y, Litzenburger M, Cheng S, Bian G, Hu B, Yan P, Cai Y, Deng Z, Bernhardt R, Liu T. 2018. Sesquiterpenoids Produced by the Combination of Two Sesquiterpene Cyclases with Promiscuous Myxobacterial CYP260B1. 

Chembio Chem Download Link

2.  Huang M, Liu B, Liu R, Li J, Chen J, Jian F, Ding H, Deng ZX, Liu T. 2018. Aglycone Polyether Nanchangmycin and Its Homologues Exhibit Apoptotic and Antiproliferative Activities against Cancer Stem Cells. 

ACS Pharmacology & Translational Science Download Link

3. Bian G, Rinkel J, Wang Z, Lauterbach L, Hou A, Yuan Y, Deng Z, Liu T, Dickschat JS. 2018. A Clade II-D Fungal Chimeric Diterpene Synthase from Colletotrichum gloeosporioides Making Dolasta-1(15), 8-diene.

Angew Chem Int Ed Engl Download Link

4. Mary A, Zhang Y, Whitney H, Wang G, Baidoo E, Liu T, Tang Y. 2018. Comparative Studies of Glycolytic Pathways and Channeling Under in Vitro and in Vivo Modes. 

AIChE Journal Download Link

5. Zhang Y, Huang Q, Deng Z, Xu Y, Liu T. 2018. Enhancing the efficiency of cell-free protein synthesis system by systematic titration of transcription and translation components. 

Biochemical Engineering Journal Download Link

6. Bian, G, Ma T, Liu T. 2018. In Vivo Platforms for Terpenoid Overproduction and the Generation of Chemical Diversity. 

Methods in Enzymology Download Link

7. Tao H, Zhang Y, Deng Z, Liu T. 2018. Strategies for Enhancing the Yield of the Potent Insecticide Spinosad in Actinomycetes. 

Biotechnology journal Download Link

8. Liu R, Deng Z, Liu T. 2018. Streptomyces species: Ideal chassis for natural product discovery and over production. 

Metabolic Engineering Download Link

9. Ding J, Liang H, Fu S, Liu R, Deng Z, Liu T. 2018. Modification of E-Poly-L-Lysine In Vivo to Reduce Self-Toxicity and Enhance Antibiotic Overproduction. 

AIChE Journal Download Link

10. Bian, G., Hou, A., Yuan, Y., Hu, B., Cheng, S., Ye, Z., ... & Liu, T. 2018. Metabolic Engineering-Based Rapid Characterization of a Sesquiterpene Cyclase and the Skeletons of Fusariumdiene and Fusagramineol from Fusarium graminearum. 

Organic letters Download Link

11. 龙燕,刘然,梁恒宇,刘天罡. Nisin高产菌株的高通量筛选.

微生物学报 Download Link


2017年

1. Tan G Y, Liu T. 2017. Rational synthetic pathway refactoring of natural products biosynthesis in actinobacteria. 

Metabolic Engineering Download Link


2. Liu Z, Zhang Y, Jia X, et al. 2017. In vitro reconstitution and optimization of the entire pathway to convert glucose into fatty acid. 

ACS Synthetic Biology Download Link

3Bian G, Yuan Y, Tao H et al. 2017. Production of taxadiene by engineering of mevalonate pathway in Escherichia coli and endophytic fungus Alternaria alternata TPF6. 

Biotechnology Journal Download Link

4.Tan G Y, Deng K H, Liu X H, et al. 2017. Heterologous biosynthesis of spinosad: an omics-guided large polyketide synthase gene cluster reconstitution in Streptomyces. 

ACS Synthetic Biology Download Link

5Bian G, Han Y, Hou A, et al. 2017. Releasing potential power of terpene synthases by a robust precursor supply platform. 

BioRxiv Download Link

6. Bian G, Deng Z, Liu T. 2017. Strategies for terpenoid overproduction and new terpenoid discovery. 

Current Opinion in Biotechnology  Download Link


2016年

1. Ma T, Zhou Y, Li X, Zhu F, Cheng Y, Liu Y, Deng Z & Liu, T. 2016. Genome mining of astaxanthin biosynthetic genes   from Sphingomonas sp. ATCC 55669 for heterologous  overproduction in Escherichia coli.

Biotechnology Journal Download Link

2. Ma T, Deng Z & Liu, T. 2016. Microbial production strategies and applications of lycopene and other terpenoids. 

World Journal of Microbiology and Biotechnology Download Link

3. Tao H, Zhang Y, Cao X, Deng Z & Liu T. 2016. Absolute quantification of proteins in fatty acid biosynthetic pathway using protein standard absolute quantification. 

Synthetic and Syetems Biotechnology Download Link

4. Tan G, Zhu F, Deng Z & Liu T. 2016. In vitro reconstitution guide for targeted synthetic metabolism of chemicals, nutraceuticals and drug precursors. 

Synthetic and Syetems Biotechnology Download Link

5. Hou A, Deng Z, Ma H, et al. 2016. Substrate screening of amino transaminase for the synthesis of a sitagliptin intermediate. 

Tetrahedron Download Link

6. Huang M, Deng Z, Tian J, et al. 2016. Synthesis and biological evaluation of salinomycin triazole analogues as anticancer agents. 

European Journal of Medicinal Chemistry Download Link

7. Ye Z, Li X, Cheng Y, et al. 2016. Evaluation of 3-hydroxypropionate biosynthesis in vitro by partial introduction of the 3-hydroxypropionate/4-hydroxybutyrate cycle from Metallosphaera sedula. 

Journal of industrial microbiology & biotechnology Download Link

8. Liu Z, Liu T. 2016 Production of acrylic acid and propionic acid by constructing a portion of the 3-hydroxypropionate/4-hydroxybutyrate cycle from Metallosphaera sedula in Escherichia coli. 

Journal of Industrial Microbiology & Biotechnology Download Link

9. 贾晓歌, 邓子新, 刘天罡. 无细胞蛋白表达体系研究进展及在生物制药领域中的应用[J]. 

微生物学报 Download Link

10. 肖丽萍,刘天罡. 链霉菌底盘细胞的开发现状及其应用

微生物学报 Download Link

11. 陆健开,刘天罡, et al. "毕赤酵母中外源表达脂肪酰-CoA 还原酶生产脂肪醇." 

微生物学通报  Download Link


2015年

1. Tao H, Guo D, Zhang Y, Deng Z & Liu T. 2015. Metabolic engineering of microbes for branched-chain biodiesel production with low-temperature property. 

Biotechnology for Biofuels, 8:92 Download Link

2. Liu Q, Wu K, Lu L, Cheng Y, Zhang Y, Deng Z & Liu T. 2015. Engineering a iterative polyketide pathway in Escherichia coli results in single-form alkene and alkane overproduction. 

Metabolic Engineering, 28, 82-90 Download Link

3. Zhu F, Lu L, Fu S, Zhong X, Hu M, Deng Z & Liu, T. 2015. Targeted engineering and scale up of lycopene overproduction in Escherichia coli. 

Process Biochemistry.  Download Link

2014年

1. Li X, Guo D, Cheng Y, Zhu F, Deng Z & Liu T. 2014. Overproduction of fatty acids in engineered Saccharomyces cerevisiae

Biotechnology and Bioengineering, 111(9), 1841-1852 Download Link

2. Zhu F, Zhong X, Hu M, Deng Z & Liu T. 2014. In vitro reconstitution of mevalonate pathway and targeted engineering of farnesene overproduction in Escherichia coli. 

Biotechnology and Bioengineering. Download Link

3. Liu R, Zhu, F, Lu L, Fu A, Lu J, Deng Z & Liu T. 2014. Metabolic engineering of fatty acyl-ACP reductase-dependent pathway to improve fatty alcohol production in Escherichia coli. 

Metabolic Engineering, 22, 10-21. Download Link

4. Guo D, Zhu J, Deng Z & Liu T. 2014. Metabolic Engineering of Escherichia coli for Production of Fatty Acid Short-Chain Esters through Combination of the Fatty Acid and 2-Keto Acid Pathways. 

Metabolic Engineering. Download Link

2012年

1.Guo X, Liu T, Deng Z, Cane DE. 2012. Essential role of the donor acyl carrier protein in stereoselective chain translocation to a fully reducing module of the nanchangmycin polyketide synthase. 

Biochemistry. 51(4):879-87. Download Link


2011年

1. Yu Q, Du A, Liu T, Deng Z, He X. 2011.The biosynthesis of the polyether antibiotic nanchangmycin is controlled by two pathway-specific transcriptional activators. 

Arch Microbiol. Nov 23. Download Link

2. Yu X, Liu T, Zhu F, Khosla C. 2011.In vitro reconstitution and steady-state analysis of the fatty acid synthase from Escherichia coli.

Proc Natl Acad Sci U S A. 108(46):18643-8.(共通讯作者,共第一作者)Download Link

3. 付爱思, 刘然, 朱静,刘天罡. 2011. 遗传改造微生物代谢途径生产新型柴油燃料的研究进展

《遗传》10 , 1121-1133 Download Link


博士后期间发表:

1. Liu T, Khosla C. 2010. A Balancing Act for Taxol Precursor Pathways in E. coli. 

Science. 330:44-45 (共通讯作者)Download Link

2. Liu T, Vora H, Khosla C. 2010. Quantitative analysis and engineering of fatty acid biosynthesis in E. coli. 

Metabolic Engineering. 12:378-86 Download Link

3. Liu T, Khosla C. 2010. Genetic Engineering of Escherichia coli for Biofuel production. 

Annual Review of Genetics. 44:53-69 (共通讯作者)Download Link


博士期间发表:

1. Xun G, Liu T, Valenzano C, Deng Z, Cane D. 2010. Mechanism and Stereospecificity of a Fully Saturating Polyketide Synthase Module: Nanchangmycin Synthase Module 2 and Its Dehydratase Domain. 

Journal of American Chemical Society. 132(42):14694-6. Download Link

2. He Y, Sun Y, Liu T, Zhou X, Bai L, Deng Z. 2010. Cloning of separate meilingmycin biosynthesis gene clusters by use of acyltransferase-ketoreductase didomain PCR amplification. 

Appl Environ Microbiol. 2010 May; 76(10):3283-92. Download Link

3. Liu T, Cane D, Deng Z. The Enzymology of Polyether Biosynthesis. 2009. 

Methods in Enzymology. 459:187-214 Download Link

4. Liu T, Lin X, Zhou X, Deng Z, Cane D. 2008. Mechanism of thioesterase-catalyzed chain release in the biosynthesis of the polyether antibiotic nanchangmycin. 

Chemistry & Biology.15, 449-58 Download Link

5. Liu T, You D, Valenzano C, Sun Y, Li J, Yu Q, Zhou X, Cane D, Deng Z. 2006. Identification of NanE as the Thioesterase for Polyether Chain Release in Nanchangmycin Biosynthesis. 

Chemistry & Biology. 13:945-55 Download Link

 
参与编写书籍:
1书籍名称:Biofuels: From Microbes to Molecules. 

出版社:Caister Academic Press,字数:12000

参与章节:第七章,Engineering Microbial Fatty Acid Biosynthetic Pathways to MakeAdvanced Biofuels

作者:宁婷婷,刘天罡

2. 书籍名称:2013工业生物技术发展报告 

出版社:科学出版社

参与章节: 8章,体外重建脂肪酸合成系统对新型生物能源工业化的指导

作者:柳志杰,刘天罡

 

获批专利:

1. 一种在异养微生物体内直接合成脂肪醇的方法 201110327887.1                 2013年授权

2. 一种利用脂肪酰ACP还原酶生物合成脂肪醇的方法 201210330969.6              2014年授权

3. 一种生产法尼烯的菌株及运用 201310209423.0                               2014年授权