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EDUCATION

2008

Ph.D. Microbiology, School of Life Science & Biotechnology Shanghai Jiaotong University, China

2006 - 2007

Exchange Ph.D student, Department of Chemistry, Brown University, USA

2002

B.S. Microbial engineering, Department of Biotechnology, Shandong University, China

PROFESSIONAL EXPERIENCE

2012 - present

Director, Hubei Engineering Laboratory for Synthetic Microbiology, China

 

Deputy Chief Engineer, Wuhan Institute of Biotechnology, China

2010 - present

Professor, Wuhan University School of Pharmaceutical Sciences, Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, China

2008 - 2010

Post-doc research fellow, Department of Chemistry, Stanford University, USA

SPECIAL HONORS:

2014

National Top-Notch Young Talents Program of National High-level Personnel of Special Support Program,  China

2012

"Chutian scholar" Professor, Hubei, China

2012

Supported by National Natural Science Funds for Excellent  Young Scholar, China

2010

New Century Excellent Talents in University, China

2006.11

National scholarship for excellent Ph.D student, Shanghai Jiaotong University, China

2000.11

The golden prize winner of the second "Challenge Cup" National College Student Business Plan Competition, China

SELECTED PROFESSIONAL POSITIONS

2016

Current Opinion in Biotechnology special issue "Pharmacetical Biotech 2017"Co-editor

2016

ACS Synthetic Biology, Editor on Board

2016

Metabolic Engineering, Editor on Board

2016

Acta microbiologica Sinica, Editor on Board

2016

Hubei Food And Drug Administration, consultant

2015

Synthetic and Systems Biotechnology, Editor on Board

2014

F1000prime, Associate Faculty Member

2013

Frontiers in Synthetic Biology, Editor on Board


SELECTED RESEARCH GRANTS

2016.01-2018.12

National Top-Notch Young Talents Program of National High-level Personnel of Special Support Program (Principal investigator)

2012.10-2016.10

The National 973 Program of China Grant (No. 2012CB721001) Project Name:  Screening, modification and standardization of biological parts for synthesis biology (Co-investigator)

2013.01-2015.12

The National Science Fund for Excellent Young Scholars(No. 31222002) Project Name:  Breeding and Genetics of Applied Microorganisms (Principal investigator)

2011.01-2015.08

The National 973 Program of China Grant (No. 2011CBA00806)Project Name: Development of bio-based production through synthetic bioengineering (Co-investigator)

PATENTS

1. Tiangang Liu, Tian Ma, Xiaowei Li, Ziling Ye, Bin Shi. “Microorganisms and their applications”. China Patent 201610817947.0, 13 September 2016

2. Tiangang Liu, Xiaowei Li, Tian Ma, Erting Xiao, Ziling Ye, Bin Shi. “A yeast for producing β-carotene and its applications”. China Patent 201510580105.3, 10 September 2015

3. Tiangang Liu, Tian Ma, Yuanjie Zhou, Fayin Zhu. "The astaxanthin biosynthetic genes of Sphingomonas and a method for Sphingomonas genetic manipulation". China Patent 201410447259.0, 03 November 2014

4. Tiangang Liu, Zhijie Liu, Yixuan Wang, Zixin Deng. “Amethod of producing 3-hydroxypropionic acid, acrylic acid and propionic acid inthe method of fixing carbon dioxide microorganisms”. China Patent201410035584.6, 24 January 2014

5. Tiangang Liu, Ran Liu, AisiFu. “Method for biologically synthesizing fatty alcohol from fatty acyl ACP(acyl carrier protein) reductase”. China Patent 201210330969.6, 01 January 2014

6Tiangang Liu, FayinZhu, Xiaoying Cao, Yuchen Zhang, Guangkai Bian, Zixin Deng. “Microbiological process for producing taxadiene and itsapplication”. China Patent 201310209544.8, 22 November2013

7. Tiangang Liu,Ran Liu, Fayin Zhu. “Method for directly synthesizing fatty alcohol inheterotrophic microorganisms”. China Patent201110327887.1, 26 October 2013

8. Tiangang Liu, Fayin Zhu,Zixin Deng. “Bacterial strain for producing farnesene and itsapplication”. China Patent 201310209421.0, 30 May 2013

9. Tiangang Liu,Fayin Zhu, Zixin Deng. “Bacterial strain for producing lycopene and itsapplication”. China Patent 201310209514.3, 30 May 2013

10. Tiangang Liu, Daoyi Guo. “Microorganisms and their function”China Patent 201310115925.6, 03 April 2013

11. Tiangang Liu, Kaiyue Wu. “Process for the production of fattyalkenes and fatty alkanes”. China Patent 201210001015, 04 January 2012

BOOK CHAPTERS

Ning, T., and Liu, T. 2014. Engineering Microbial Fatty Acid Biosynthesis Pathways to Make Advanced Biofuels. P197-218. In: Biofuels, from mircobes to moleculars, Eds. Xuefeng Lu. Caister Academic Press, U.K.

Zhi, L., and Liu, T. 2013. New strategies for development of production of biofuels via the in vitro reconstitution of the fatty acid. Chapter 8, In: 2013 Industrial biotechnology development report. Eds. Yanhe Ma. Science Press, China

CONFERENCES

2016

The 13th International Symposium on the Genetics of Industrial Microorganisms (GIM2016), Wuhan, China, plenary speech

2016

Metabolic Engineering 11, Japan, Invited talk, Feature speaker

2015

The 7th Copenhagen Bioscience Conference, FAVRHOLM CAMPUS, Danmark, Oral presentation

2014

Annual Congress of the Chinese Society for Microbiology, Harbin, China

Invited Presentation

2013

InnoAsia, Hong Kong, China, Oral presentation

2013

The 7th China Summit Forum on Industrial Biotechnology Development, Tianjing, China,  Oral presentation

2012

The 6th China Summit Forum on Industrial Biotechnology Development, Chengdu, China,  Oral presentation

2011

The 5th China Summit Forum on Industrial Biotechnology DevelopmentQingdao, China, Invited Presentation

2010

The 4th China Summit Forum on Industrial Biotechnology DevelopmentHangzhou, China, Oral presentation

2010

The 32nd Symposium on Biotechnology for Fuels and Chemicals, Florida, USA,

Invited Presentation

2010

Annual meeting of the Society for Industrial Microbiology, San Francisco, USA,

Invited Presentation

2007

PKS-NRPS Meeting at Brown University, USA, Oral presentation

2007

234th ACS National Meeting at Boston, USA, Poster

PUBLICATIONS

1.        Bian G, Deng Z, Liu T. 2017. Strategies for terpenoid overproduction and new terpenoid discovery. Current Opinion in Biotechnology  

2.        Bian G, Han Y, Hou A,Yuan Y, Liu X, Deng Z, Liu T (2017) Releasing potential power of terpene synthases by a robust precursor supply platform. bioRxiv

3.        Bian, G., Yuan, Y., Tao, H., Shi. X., Zhong, X., Han,Y., Fu, S., Fang, C., Deng, Z., Liu, T. (2017). Production of Taxadiene by engineering ofmevalonate pathway in Escherichia coliand endophylic fungus Alternariaalternata TPF6. BiotechnologyJournal. Accepted.

4.        Liu, Z., Zhang, Y., Jia, X., Hu, M., Deng, Z., Xu, Y., Liu T. (2017). In VitroReconstitution and Optimization of the Entire Pathway to Convert Glucose intoFatty Acid. ACS Synth Bioldoi: 10.1021/acssynbio.6b00348

5.        Tan, G., Liu, T. (2016).Rational synthetic pathway refactoring ofnatural products biosynthesis in actinobacteria. MetabolicEngineering. http://dx.doi.org/10.1016/j.ymben.2016.12.006.

6.        Liu,Q., Xiao, L., Zhou, Y., Deng, K., Tan, G., Han, Y., Liu, X., Deng, Z., Liu, T. (2016). Development ofStreptomyces sp. FR-008 as an Emerging Chassis. Synthetic and SystemsBiotechnology. 1:207-214.

7.        Tan,G., Zhu, F., Deng, Z., Liu, T.(2016). In vitro Reconstitution guide for targeted synthetic metabolism ofchemicals, nutraceuticals and drug precursors. Synthetic and SystemsBiotechnology. 1(1):25-33.

8.        Tao,H., Zhang, Y., Cao, X., Deng, Z., Liu,T. (2016). Absolute Quantification of Proteins in the Fatty AcidBiosynthetic Pathway Protein Standard Absolute Quantification. Syntheticand Systems Biotechnology. 1(1):150-157

9.        Huang, M., Deng, Z., Tian, J., Liu, T. (2016). Synthesis and biological evaluation ofsalinomycin triazole analogues as anticancer agents. European Journal of MedicinalChemistry. http://dx.doi.org/10.1016/j.ejmech.2016.10.067

10.        Liu, Z., Liu, T. (2016). Production of acrylic acid and propionic acid byconstructing a portion of the 3hydroxypropionate/4hydroxybutyrate cycle from Metallosphaera sedula inEscherichia coli. J Ind Microbiol Biotechnol. 43:1659-1670.

11.        Hou, A., Deng, Z., Ma, H., Liu, T. (2016). Substrate screening of amino transaminase forthe synthesis of a sitagliptin intermediate. Tetrahedron. 72(31):4660-4664

12.     Ye,Z., Li, X., Cheng, Y., Liu, Z., Tan, G., Zhu, F., Fu, A., Deng, Z., Liu, T. (2016). Evaluation of 3-hydroxypropionate biosynthesisin vitro by partial introduction of the 3-hydroxypropionate/4-hydroxybutyratecycle from Metallosphaera sedula. J Ind Microbiol Biotechnol .43:1313-321.

13.    Ma,T., Deng, Z., Liu, T. (2016).Microbial production strategies and applications of lycopene and otherterpenoids. World Journal of Microbiology and Biotechnology. 32:15.

14.    Ma,T., Zhou, Y., Li, X., Zhu, F., Cheng, Y., Li. Y., Deng, Z., Liu, T. (2016). Genome mining ofastaxanthin biosynthetic genes from Sphingomonas sp. ATCC 55669 forheterologous overproduction in E. coli. Biotechnology Journal. 11:228–237

15.    Tao,H., Guo, D., Zhang, Y., Deng, Z., Liu,T. (2015). Metabolic engineering of microbes for branched-chainbiodiesel production with low-temperature property. Biotechnology for Biofuels.8:92.

16.    Tan,G., Deng, Z., Liu, T. (2015).Recent advances in the elucidation of enzymatic function in natural productbiosynthesis. F1000 Research.

17.    Zhu,F., Lu, L., Fu, S., Zhong, X., Hu, M., Deng, Z., Liu, T. (2015). Targeted engineering and scale up oflycopene overproduction in Escherichia coli. Process Biochemistry. 50,341-346.

18.    Liu,Q., Wu, K., Lu, L., Cheng, Y., Zhang, Y., Deng, Z., Liu, T. (2015). Engineering an iterative polyketide pathwayin Escherichia coli results in single-form alkene and alkane overproduction. MetabolicEngineering. 28, 82-90.

19.    Liu,R., Zhu, F., Lu, L., Fu, A., Lu, J., Deng, Z., Liu, T. (2014). Metabolic engineering of fatty acyl-ACPreductase-dependent pathway to improve fatty alcohol production in Escherichia coli. Metabolic engineering. 22,10-21.

20.     Li, X., Guo, D.,Cheng, Y., Zhu, F., Deng, Z., Liu, T.(2014). Overproduction of fatty acids in engineered Saccharomyces cerevisiae. Biotechnologyand bioengineering. 111(9):1841-52

21.    Guo,D., Zhu, J., Deng, Z., Liu, T.(2014). Metabolic Engineering of Escherichiacoli for Production of Fatty Acid Short-Chain Esters through Combination ofthe Fatty Acid and 2-Keto Acid Pathways. Metabolic engineering. 22, 69-75

22.    Wang,J., Nie, Y., Lu, Y., Liu, J., Wang, J., Fu, A., Liu, T. & Xia, J.(2014). Assembly of Multivalent Protein Ligands and Quantum Dots: AMultifaceted Investigation. Langmuir.30, 2161–2169

23.     Zhu, F., Zhong, X.,Hu, M., Lu, L., Deng, Z., Liu, T. (2014).In vitro reconstitution of mevalonate pathway and targeted engineering offarnesene overproduction in Escherichiacoli. Biotechnology andbioengineering. 111, 1396-1405

24.     Liu, T.,Khosla C. (2010). A Balancing Act for Taxol Precursor Pathways in E. coli. Science.330:44-45

25.     Liu, T.,Vora H, Khosla C. (2010). Quantitative analysis and engineering of fatty acidbiosynthesis in E. coli. Metabolic Engineering. 12:378-86

26.     Liu, T.,Khosla C. (2010). Genetic Engineering of Escherichia coli for Biofuelproduction. Annual Review of Genetics. 44:53-69

27.     Liu, T.,CaneD, Deng Z. (2009).The Enzymologyof Polyether Biosynthesis. Methods in Enzymology. 459:187-214

28.     Liu, T., Lin X, Zhou X,Deng Z, Cane D. (2008). Mechanism ofthioesterase-catalyzed chain release in the biosynthesis of the polyetherantibiotic nanchangmycin. Chemistry & Biology.15, 449-58

29.     Liu, T., You D,Valenzano C, Sun Y, Li J, Yu Q, Zhou X, Cane D, Deng Z. (2006). Identificationof NanE as the Thioesterase for Polyether Chain Release in NanchangmycinBiosynthesis. Chemistry & Biology.13945–955