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    In Wuhan University as an independent PI:


    1. Ma T, Shi B, Ye Z, et al. 2019. Lipid engineering combined with systematic metabolic engineering of Saccharomyces cerevisiae for high-yield production of lycopene[J]. Metabolic engineering.

    Metabolic Engineering Download Link

    2.Abernathy, M. H., Zhang, Y., Hollinshead, W. D., Wang, G., Baidoo, E. E., Liu, T., & Tang, Y. J. 2019. Comparative studies of glycolytic pathways and channeling under in vitro and in vivo modes.

    AIChE Journal Download Link

    3. Xiaojie Wang, Zixin Deng, Tiangang Liu*.2019. Marker-free system using ribosomal promoters enhanced xylose/glucose isomerase production in Streptomyces rubiginosus. biotechnology journal,(accepted)

    biotechnology journal Download Link

    4. Yingying Chang, Baozhong Chai, Yunkun Ding, Min He, Linghui Zheng, Yun Teng, Zixin Deng, Yi Yu*, Tiangang Liu*.2019. Overproduction of gentamicin B in industrial strain Micromonospora echinospora CCTCC M 2018898 by cloning of the missing genes genR and genS. Metabolic engineering communications. (accepted)

    Metabolic engineering communications Download Link


    1. Yuan Y, Litzenburger M, Cheng S, Bian G, Hu B, Yan P, Cai Y, Deng Z, Bernhardt R, Liu T. 2018. Sesquiterpenoids Produced by the Combination of Two Sesquiterpene Cyclases with Promiscuous Myxobacterial CYP260B1. 

    Chembio Chem Download Link

    2. Huang M, Liu B, Liu R, Li J, Chen J, Jian F, Ding H, Deng ZX, Liu T. 2018. Aglycone Polyether Nanchangmycin and Its Homologues Exhibit Apoptotic and Antiproliferative Activities against Cancer Stem Cells. 

    ACS Pharmacology & Translational Science Download Link

    3. Bian G, Rinkel J, Wang Z, Lauterbach L, Hou A, Yuan Y, Deng Z, Liu T, Dickschat JS. 2018. A Clade II-D Fungal Chimeric Diterpene Synthase from Colletotrichum gloeosporioides Making Dolasta-1(15), 8-diene.

    Angew Chem Int Ed Engl Download Link

    4. Mary A, Zhang Y, Whitney H, Wang G, Baidoo E, Liu T, Tang Y. 2018. Comparative Studies of Glycolytic Pathways and Channeling Under in Vitro and in Vivo Modes. 

    AIChE Journal Download Link

    5. Zhang Y, Huang Q, Deng Z, Xu Y, Liu T. 2018. Enhancing the efficiency of cell-free protein synthesis system by systematic titration of transcription and translation components. 

    Biochemical Engineering Journal Download Link

    6. Bian, G, Ma T, Liu T. 2018. In Vivo Platforms for Terpenoid Overproduction and the Generation of Chemical Diversity. 

    Methods in Enzymology Download Link

    7. Tao H, Zhang Y, Deng Z, Liu T. 2018. Strategies for Enhancing the Yield of the Potent Insecticide Spinosad in Actinomycetes. 

    Biotechnology journal Download Link

    8. Liu R, Deng Z, Liu T. 2018. Streptomyces species: Ideal chassis for natural product discovery and over production. 

    Metabolic Engineering Download Link

    9. Ding J, Liang H, Fu S, Liu R, Deng Z, Liu T. 2018. Modification of E-Poly-L-Lysine In Vivo to Reduce Self-Toxicity and Enhance Antibiotic Overproduction. 

    AIChE Journal Download Link

    10. Bian, G., Hou, A., Yuan, Y., Hu, B., Cheng, S., Ye, Z., ... & Liu, T. 2018. Metabolic Engineering-Based Rapid Characterization of a Sesquiterpene Cyclase and the Skeletons of Fusariumdiene and Fusagramineol from Fusarium graminearum. 

    Organic letters Download Link


    1. Tan G Y, Liu T. 2017. Rational synthetic pathway refactoring of natural products biosynthesis in actinobacteria. 

    Metabolic Engineering Download Link

    2. Liu Z, Zhang Y, Jia X, et al. 2017. In vitro reconstitution and optimization of the entire pathway to convert glucose into fatty acid. 

    ACS Synthetic Biology Download Link

    3. Bian, G., Yuan, Y., Tao, H. et al. 2017. Production of taxadiene by engineering of mevalonate pathway in Escherichia coli and endophytic fungus Alternaria alternata TPF6. 

    Biotechnology Journal Download Link

    4. Tan G Y, Deng K H, Liu X H, et al. 2017. Heterologous biosynthesis of spinosad: an omics-guided large polyketide synthase gene cluster reconstitution in Streptomyces. 

    ACS Synthetic Biology Download Link

    5Bian G, Han Y, Hou A, et al. 2017. Releasing potential power of terpene synthases by a robust precursor supply platform. 

    BioRxiv  Download Link

    6Bian G, Deng Z, Liu T. 2017. Strategies for terpenoid overproduction and new terpenoid discovery. 

    Current Opinion in Biotechnology  Download Link


    1. Ma T, Zhou Y, Li X, Zhu F, Cheng Y, Liu Y, Deng Z & Liu, T. 2016. Genome mining of astaxanthin biosynthetic genes   from Sphingomonas sp. ATCC 55669 for heterologous  overproduction in Escherichia coli.

    Biotechnology Journal Download Link

    2. Ma T, Deng Z & Liu, T. 2016. Microbial production strategies and applications of lycopene and other terpenoids. 

    World Journal of Microbiology and Biotechnology Download Link

    3. Tao H, Zhang Y, Cao X, Deng Z & Liu T. 2016. Absolute quantification of proteins in fatty acid biosynthetic pathway using protein standard absolute quantification. 

    Synthetic and Syetems Biotechnology Download Link

    4. Tan G, Zhu F, Deng Z & Liu T. 2016. In vitro reconstitution guide for targeted synthetic metabolism of chemicals, nutraceuticals and drug precursors. 

    Synthetic and Syetems Biotechnology Download Link

    5. Hou A, Deng Z, Ma H, et al. 2016. Substrate screening of amino transaminase for the synthesis of a sitagliptin intermediate. 

    Tetrahedron Download Link

    6. Huang M, Deng Z, Tian J, et al. 2016. Synthesis and biological evaluation of salinomycin triazole analogues as anticancer agents. 

    European Journal of Medicinal Chemistry Download Link

    7. Ye Z, Li X, Cheng Y, et al. 2016. Evaluation of 3-hydroxypropionate biosynthesis in vitro by partial introduction of the 3-hydroxypropionate/4-hydroxybutyrate cycle from Metallosphaera sedula. 

    Journal of industrial microbiology & biotechnology Download Link

    8. Liu Z, Liu T. 2016 Production of acrylic acid and propionic acid by constructing a portion of the 3-hydroxypropionate/4-hydroxybutyrate cycle from Metallosphaera sedula in Escherichia coli. 

    Journal of Industrial Microbiology & Biotechnology Download Link


    1. Tao H, Guo D, Zhang Y, Deng Z & Liu T. 2015. Metabolic engineering of microbes for branched-chain biodiesel production with low-temperature property. 

    Biotechnology for Biofuels Download Link

    2. Liu Q, Wu K, Lu L, Cheng Y, Zhang Y, Deng Z & Liu T. 2015. Engineering a iterative polyketide pathway in Escherichia coli results in single-form alkene and alkane overproduction. 

    Metabolic Engineering Download Link

    3. Zhu F, Lu L, Fu S, Zhong X, Hu M, Deng Z & Liu, T. 2015. Targeted engineering and scale up of lycopene overproduction in Escherichia coli. 

    Process Biochemistry.  Download Link


    1. Li X, Guo D, Cheng Y, Zhu F, Deng Z & Liu T. 2014. Overproduction of fatty acids in engineered Saccharomyces cerevisiae

    Biotechnology and Bioengineering Download Link

    2. Zhu F, Zhong X, Hu M, Deng Z & Liu T. 2014. In vitro reconstitution of mevalonate pathway and targeted engineering of farnesene overproduction in Escherichia coli.  

    Biotechnology and Bioengineering Download Link

    3. Liu R, Zhu, F, Lu L, Fu A, Lu J, Deng Z & Liu T. 2014. Metabolic engineering of fatty acyl-ACP reductase-dependent pathway to improve fatty alcohol production in Escherichia coli.  

    Metabolic Engineering Download Link

    4. Guo D, Zhu J, Deng Z & Liu T. 2014. Metabolic Engineering of Escherichia coli for Production of Fatty Acid Short-Chain Esters through Combination of the Fatty Acid and 2-Keto Acid Pathways.  

    Metabolic Engineering. Download Link


    1. Guo X, Liu T, Deng Z, Cane DE. 2012. Essential role of the donor acyl carrier protein in stereoselective chain translocation to a fully reducing module of the nanchangmycin polyketide synthase. 

    Biochemistry  Download Link


    1. Yu Q, Du A, Liu T, Deng Z, He X. 2011.The biosynthesis of the polyether antibiotic nanchangmycin is controlled by two pathway-specific transcriptional activators. 

    Arch Microbiol. Nov 23. Download Link

    2. Yu X, Liu T, Zhu F, Khosla C. 2011.In vitro reconstitution and steady-state analysis of the fatty acid synthase from Escherichia coli.

    Proc Natl Acad Sci U S A. 108(46):18643-8.(co-first authors, co-corresponding authors)Download Link

    3. Genetic engineering of microbial metabolic pathway for production of advanced biodiesel

    Hereditas 10, 1121-1133 Download Link

    In Stanford University as post-doc research fellow:

    1. Liu T, Khosla C. 2010. A Balancing Act for Taxol Precursor Pathways in E. coli. 

    Science. 330:44-45 (co-corresponding authors)Download Link

    2. Liu T, Vora H, Khosla C. 2010. Quantitative analysis and engineering of fatty acid biosynthesis in E. coli. 

    Metabolic Engineering. 12:378-86 Download Link

    3. Liu T, Khosla C. 2010. Genetic Engineering of Escherichia coli for Biofuel production. 

    Annual Review of Genetics. 44:53-69 (co-corresponding authors)Download Link

    In SJTU and Brown University as Ph. D student:

    1. Xun G, Liu T, Valenzano C, Deng Z, Cane D. 2010. Mechanism and Stereospecificity of a Fully Saturating Polyketide Synthase Module: Nanchangmycin Synthase Module 2 and Its Dehydratase Domain. 

    Journal of American Chemical Society. 132(42):14694-6. Download Link

    2. He Y, Sun Y, Liu T, Zhou X, Bai L, Deng Z. 2010. Cloning of separate meilingmycin biosynthesis gene clusters by use of acyltransferase-ketoreductase didomain PCR amplification. 

    Appl Environ Microbiol. 2010 May; 76(10):3283-92. Download Link

    3. Liu T, Cane D, Deng Z. The Enzymology of Polyether Biosynthesis. 2009. 

    Methods in Enzymology. 459:187-214 Download Link

    4. Liu T, Lin X, Zhou X, Deng Z, Cane D. 2008. Mechanism of thioesterase-catalyzed chain release in the biosynthesis of the polyether antibiotic nanchangmycin. 

    Chemistry & Biology.15, 449-58 Download Link

    5. Liu T, You D, Valenzano C, Sun Y, Li J, Yu Q, Zhou X, Cane D, Deng Z. 2006. Identification of NanE as the Thioesterase for Polyether Chain Release in Nanchangmycin Biosynthesis. 

    Chemistry & Biology. 13:945-55 Download Link


    1. Ning T, Liu T. (2014) Chapter 7: Engineering Microbial Fatty Acid Biosynthetic Pathways to MakeAdvanced Biofuels. Biofuels: From Microbes to Molecules.  Caister Academic Press.    
    2. Liu Z, Liu T. (2013) Chapter 8: In vitro Reconstitution of Fatty Acid Biosynthesis System to Guide Industrialization of New Biofuels. 2013 Industrial biotechnology development report. Science Press.